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The Venture 17 Division Of Education



THE CONSERVATORY OF MEDICAL ARTS AND SCIENCES

XVII

MICROBIOLOGY LIBRARY AND COURSE

Large library. Please allow to load.

German engineering has been at the forefront of all major advancements in modern medical science. Heinrich Hermann Robert Koch was a German physician and a pioneer in the specialty of Infectious Diseases. He became famous for isolating Bacillus anthracis (1877), Tuberculosis bacillus (1882), and Vibrio cholera (1883).

He is also known for his development of Koch's Postulates which continue to be utilized in the laboritories of the twentyfirst century.

He was awarded the Nobel Prize in Medicine for his tuberculosis findings in 1905. A contemporary of Louis Pasteur, He is considered one of the founders of microbiology, inspiring such major figures as Paul Ehrlich and Gerhard Domagk.

Below is our image library from Advanced Microbiology. These images are one of the complete sets of images in Microbiology and Infectious Diseases utilized by The Conservatory Associate Faculty when lecturing in Advanced Microbiology. The library and course tools remain dynamic and are updated regularly.

This reference library is currently under reconstruction. When finished, it will contain over 400 images with accompanying academics. From cultivation of bacteria, virology and detection methods, to bio-terrorism, it will be comprehensive.

There are 5 lecture sets. The images can be manipulated by the user. You can pause, or advance the stream at your discretion. Just point at the image and it will instruct you.

Images from the entire course are archived chronologically when the course is on sabbatical. You can point and click the archive images to enlarge and view as a slide presentation.

The Conservatory teaches Advanced Microbiology for students in Colorado year-round, and offers an online textbook. This tool allows us to present Microbiology as an online resource and course available at no cost to our students. This is not only available as an assistant to the students we teach on campus, but is available to anyone wanting to increase their medical knowledge and competitive edge.

For you to be able to utilize this system at no cost, you must sign into We Teach College Students. After confirmation of student status, we will add you to our roster and email your access codes within twenty-four hours.


Keep in mind that this is a large and concise textbook on Microbiology, with case studies, illustrations, color photography, study guides, and web-links. In addition, the related links are robust and can take your studies as far as you wish. 

Bacillus anthracis

Electron microscopy showing spores within.

Anthrax can be weaponized and is a known terrorist threat.

The dermatitic "Black Eschar"

"Wool Sorters Disease", Anthrax pneumonia is a killer.

An aerosolized anthrax weapon, is a weapon of mass destruction.You will have obligations to the CDC and USAMRIID if this bug is isolated in your lab.

BAP Agar

B. anthracis on BAP

Artist's rendering of the spored bacillus

The spores are the infectors.

Know this look.

"The Medusa Head"

Know this look.

"Medusa Head" or "Curly Hair" colony edges

Bacillus cereus

Bacillus cereus

Hemolysins and enterotoxins from B.C.

Food borne illness

B. cereus on BAP

PCN resistant

Moraxella catarrhalis on BAP

Behaves much like Neisserians.

Moraxella catarrhalis. A gram negative coccus related to Neisserians

Has changed its name twice in 30 years

A well known URI and Otitis inducer

It also attacks the LRT

C & S on BAP

M. cat.

The gram negative flagilate bacillus Vibrio spp.

The Vibrio organism

Vibrio cholerae

Electron microscopy

Vibrio cholerae, a known killer, invades the GI tract

Light microscopy of this "Rice Water" diarrhea inducer.

"What's that smell ?"

Amine production of Gardnerella sp.

A great microbiologist

Ella Gardner found out what that smell was.

Gardnerella vaginalis

Electron microscopy

Vaginosis of G.V.

An increased vaginal pH is present

"Clue Cells"

Epithelial cells coated with gram variable to gram negative coccobacilli

10% (K+OH-) solution

The "Whiff Test"

Eikenella corrodens

GNB

Endocarditis

Eikenella corrodens

Bite wounds

Eikenella corrodens

E.C. grows on chocolate and BAP

Eikenella corrodens

It appears to corrode the agar and smells like bleach

Hence its name

Aeromonas hydrophila

Aeromonas hydrophila, gram negative, facultative anaerobes

Grown on BAP

Poison our seafood and drinking water

Causes wound infections and LRIs along with G.I. infections

Wound infected by waterborne Aeromonads

Lactobacillus spp. are gram positive rods. Form strep like chains

Light microscopy

Not generally a disease producer.

Electron microscopy

Lactobacillus sporogenes

A schematic of the organism

Tiny rough gray colonies

No special media required

Lactobacilli

Lactobacilli are the active cultures in yogurt and other products

Erysipelas, from Greek, meaning "Red Skin"

aka Erysipeloid

A gram positive pleomorph

We catch it from animals (livestock)

Chromobacterium violaceum

It produces a naturally occuring antibiotic called Violacein.

Chromobacterium violaceum on nutrient agar

Note the metalic appearing colonies with violet pigment.

The Gonococcus

Gram negative diplococcus

Neisseria meningitidis

This gram negative organism is a well known killer. Our only weapon, vaccination.

Neisseria spp. here on LKV

A special agar to isolate via anyibiotics.

Neisserians are Oxidase +, and Catalase +, but gram negative cocci, usually diplococcoid

N. meningitidis

Unrelenting. Can be killed with PCNs

But N. meningitidis' deadly endotoxin is what kills. It is also antiphagocytic.

Pretty but unholy killer

N. meningitidis

The Brudzinski sign

Inflamed meninges

The classic Petechiae of the meningococcal attack

An ominous sign.

What it does. Inflamed meninges

It tortures, then kills. Usually children and young adults.

Sepsis usually kills before meningitis has a chance to take hold

Survivors have MI's, CVA's, loss of limb, blindness, and renal failure.

Gonococcal infection

Neonatal ophthalmia

Gonorrhea

The word "clap", which is another name for this disease, was coined during the American Civil War ( from the sound the butt of a rifle would make when breaking up adhesions).

Clostridium botulinum

The clostridials are gram positive spore forming anaerobes

Clostridium species

The "Tennis Racket" or "Club" of clostridials

Botulinum toxin

Canned food

The Botox

Botulinum toxin is a paralyzer.

Clostridium perfringens

Gas Gangrene

C. perfringens

C. perfringens on LKV

C. perfringens

Microscopy

Clostridium tetani

Tetnus. Clostridium tetani. It lives in the soil

Clostridium tetani

Pretty under the electron microscope.

Clostridium difficile

attacks the G.I.tract

Usually the result of antibiotic therapy for another condition.

especially clindamycin

Diarrhea and Pseudomembraneous colitis

This can be fatal.

The pseudomembrane

Can obstruct and kill.

Actinomyces israelii

Gram + non spore forming anaerobe

Lumpy jaw

Actinomyces israelii

actinomycotic skin abscess

Actinomyces israelii

Madura foot

Actinomyces israelii

Peptostreptococcus anaerobius

Gram + anaerobic cocci

P. anaerobius throat

Could be any catarrhal infector.

Peptostreptococci

Peptostreptococci chain up like streptococci

Bacteroides fragilis

Gram + anaerobic cocci

Bacteroides fragilis

Here, on Bile Esculin Agar

Bacteroides fragilis

colonies

Egg Yolk Agar

To grow clostridia spp.

Clostr. spp. on CCFA

A special agar to isolate clostridials

Clostr spp. on CCFA

Another view

Laked Kanamycin Vancomycin Agar

Bacteroides

Phenylethyl Alcohol agar

Used to grow Clostridia in presence of enteric GNB's

PYG broth based

nonselective for cultivation of anaerobes for GLC analysis

Cooked meat agar

nonselective for cultivation of anaerobes for GLC analysis

The Angel of Death

The Acid Fast Bacillus

Tuberculosis

What the acid fast bacillus does

Tuberculosis complex

The Gohn

It kills 3,000,000 people a year

Tuberculosis

Here on culture medium

It grows in clumps

The tubercular complexes of the pulmonary invasion

TB pneumonitis

Electron microscopy

Tuberculosis

The cavitary lesions of advanced pulmonary tuberculosis

They remain hemorrhagic.

Tuberculosis

It likes the apices of the lungs

Pulmonary TB

Hemorrhagic cavitations of TB

Antibiotic Weaponry Against TB

Designer drugs trying to keep up with resistance.

Leprosy

Leprosy, now called Hansen's Disease, is a cousin of Tuberculosis

Mycoplasma Pnuemoniae

Just a little bigger than a large virus

The atypical pneumonia of mycoplasma

Not a true consolidation.

The inner sanctum of mycoplasma

The size of a large virus, it lacks a cell wall.

Mycoplasma can kill

Pnuemonia

Mycoplasma attacks respiratory epithelia

It prefers cilliated epithelias

The Atypical pneumonitis of Mycoplasma

Microscopy

Ureaplasma

Mycoplasma type organisms in the urine

A rendering of Ureaplasma‚Äč